Juventix Blogs

Platelet Rich Fibrin Bio-Filler

By November 8, 2022April 16th, 2024No Comments

The global non-invasive aesthetic treatment market size is anticipated to reach US $133.87 billion by 2029.

The annual rate of growth from 2021 to 2030 is estimated at 12.4%

The non-invasive market includes treatments operating without medical instruments.

These procedures have been found to be beneficial as aesthetic treatments with various medical equipment sometimes results in complications. Also, non-invasive treatments virtually has no scarring and coupled with the lower cost of these procedures, they are extremely popular among millennial and generation Z age groups.

Aging in the millennial group has been the major factor driving this market. Sagging skin, wrinkles in the face specifically around the eyes and lips as well as age spots are the major areas of concern. Botox and dermal fillers are the two primary treatments for these abnormalities.

Botox injections are widely preferred non-invasive cosmetic procedure in the US and in 2019, 4.4 million were documented by the American Society of Plastic Surgeons.

Based on the product type, the non-invasive aesthetic treatment are separated into three categories,

  • Injectable
  • Skin rejuvenation
  • Others


  • Hyaluronic Acid
  • Polymer Filler
  • Calcium Hydroxylapatite
  • Collagen
  • Botulinum Toxin

Skin Rejuvenation

  • Chemical Peel
  • Photo-Rejuvenation
  • Laser Skin Resurfacing


  • Non-Surgical Fat Reduction
  • Hair Removal and Growth
  • Cellulite Treatment
  • Sclerotherapy

The filler market was valued at 5.08 billion USD in 2021 and expected to continue to grow at an annual rate of 7.9%.

The cost on average of one syringe of hyaluronic acid filler is $600-$800.

Polylactic filler cost is one syringe at $850-$1000.

Polymethyl-methacrylate microsphere filler is $1000-$1200.

Side effects of fillers

Common side effects of fillers include, bruising, redness, swelling, pain, tenderness, itching, rash, difficulty with movement.

More serious side effects include, weakness of the muscles of the face, head and neck, allergic reactions, double vision, infections and the death of cells.

Long-term stretching of the skin causes disturbance of the fat pads and irregularity, lymphatic blockage and aging of the skin. Injection into a vessel can have catastrophic results of necrosis. There has also been reported one case of blindness from a filler injection in the glabellar region.

Platelet Rich Plasma

Platelet Rich Plasma has been used as a treatment modality for skin rejuvenation for the past decade and this blood derived concentrate is now extensively being used in the aesthetic market. Platelets are the logical choice for replacement and renewal of cells, tissues or other damaged areas due to their high healing potential, easy availability, low cost and excellent side effect profile. PRP is rich in growth factors and cytokines and is considered to be a growth cocktail promoting wound healing, angiogenesis and tissue remodeling.

Studies vary in the amount and differentiation of the growth factors contained on the platelets, but the major growth factors are:

  • Platelet derived growth factor- promotes angiogenesis and collagen production also mitogen for fibroblasts and smooth muscle cells
  • Vascular endothelial growth factor-promoting angiogenesis
  • Transforming growth factor beta- increases collagen
  • Epidermal growth factor- promoting cell growth, differentiation, angiogenesis and collagen production
  • Pro-inflammatory cytokines- stimulating fibroblasts and collagen synthesis

PRP can activate fibroblasts and synthesize collagen and other tissues of the fibrin matrix and therefore an attractive option for skin and tissue rejuvenation and scar attenuation. The use of PRP as monotherapy for aesthetic applications is increasing rapidly.

Tissue loss following inflammation and volume loss due to aging are common and difficult to treat. Dermal fillers are quite effective in restoring volume in these conditions, but the cost is prohibitive for many. Also, side effects from long term use of fillers concern many people. An innovative solution to this problem is the use of platelet rich plasma bio-filler or also called platelet rich fibrin.

Plasma proteins can be coagulated using heat to form a gel like substance which can be safely injected into the face and other areas to provide volume replacement. The heat also generates a change in the cytokines and growth factors. The inflammatory state of PRP is modulated and it now becomes anti-inflammatory. The fibrin becomes a scaffold upon which cytokines and growth factors can now build and regenerate new tissue.

When this PRF is combined with hyaluronic acid, the environment becomes hydrophilic and attracts the bodies own stem cells and other bio-active proteins.

The use of Platelet Rich Fibrin originated in dentistry where a fibrin clot generated for PRP is packed into an area of extraction to rebuild bone and surrounding tissues. With the heating of platelet rich plasma an injectable compound is generated. This is highly useful in aesthetics rather than the other more expensive and potentially dangerous fillers commonly used.

Studies confirming the use of bio-filler generated by the heating process

J Cosmet Dermatol 2019 Feb 26 PMID 3080-9897

Background: The popularity of dermal fillers has grown rapidly in the last few years for facial rejuvenation. Plasma Gel is an autologous gelatinous material that is prepared from the patient’s own platelet poor plasma. The objective was to evaluate the clinical efficacy and safety of plasma gel injection as a dermal filler for facial rejuvenation.

Conclusion: Autologous platelet poor plasma gel injection seems to be a cost effective, safe, well tolerated, and minimally invasive technique producing significant aesthetic correction of facial wrinkles and tear trough deformity.

Dermatol Ther 2020 Nov;33(6): e14255 PMID 32862476

Purpose: Infraorbital dark circles and tear trough deformity are considered common aesthetic problems. Numerous therapeutic modalities have been suggested with variable outcomes. The aim of this study was to compare the efficacy of platelet poor plasma gel vs platelet rich plasma in infraorbital rejuvenation.

Conclusion: It could be concluded that both gel and prp were clinically effective procedures for aesthetic improvement of the infraorbital region. Moreover, the gel seems to be significantly more effective than prp as a therapeutic modality.

Arch Dermatol Res 2022 Sep;314(7): 661-671. PMID 34231136

Background: Periorbital skin is the thinnest. That is why, it is the easiest to wrinkle and the most challenging to rejuvenate. Platelet Rich Plasma as well as plasma gel have been used for skin rejuvenation and considered relatively safe and effective.

This was a split face study.

Conclusion: Two sessions of both PRP and plasma gel are effective for periorbital rejuvenation, with plasma gel showing significantly better results. However, improvement was not well maintained for 3 months.

(Authors note: only 2 injections of PRP and PRF were done in this study)

The results of these and other studies concerning the aesthetic use of platelet rich fibrin are favorable. The name of Plasma Gel has now been replaced with Platelet Rich Fibrin. The use of PRP and PRF has the advantages of reducing side effects, immunological reactions and disease transmission. This makes the aesthetic use of these concentrates safer, well tolerated, lower cost with minimal to no adverse effects.

Juventix Regenerative Medical is an industry leader in the regenerative medical field. Our Platelet Rich Plasma Kits are FDA approved and designed for safety and effectiveness. They are cost effective and easy to use. The kits provide consistency of concentrated product when obtained from the same source.

Juventix Regenerative Medical offers a patent pending LED Activator to activate the platelets and begin the regenerative cascade. The activation is a critical process to release the highest quantity of cytokines and growth factors. This activation is accomplished with LED light and not by the addition of chemicals such as calcium chloride or thrombin.

Juventix Regenerative Medical supplies a Bio-Incubator that transforms the Platelet Rich Plasma into an injectable Platelet Rich Fibrin. This PRF is commonly called the “second generation of platelet products” and has a broad range of clinical applications due to the different cytokines, growth factors and bio-active proteins versus platelet rich plasma.

Juventix Regenerative Medical has a PRP Kit that contains non-cross linked hyaluronic acid. This kit is used for many different medical disease states but primarily in the aesthetic field in place of other fillers. This HA PRP Kit, used with the other Juventix devices for activation and bio-incubation, provides the patient and clinician with an alternative to the commonly used fillers in the market today at a lower cost and improved side effect profile.



Regenerative Regards,


Dr. Robert McGrath

Leave a Reply