Facial Aging – What Can Be Done About It?
Facial aging is a multifactorial process influenced by both intrinsic and extrinsic factors. It is manifested by a loss of skin elasticity, volume depletion and the formation of wrinkles. Recent advances in regenerative medicine have led to multiple treatments to turn back the clock and restore youthful skin by stimulating the natural healing processes. These new regenerative therapies include platelet rich plasma, platelet rich fibrin, exosomes, microneedling, and peptides that are delivered by new devices, some needleless.
Causes of Facial Aging
Facial aging is a combination of both extrinsic and intrinsic factors.
Extrinsic Factors – Ultraviolet radiation, pollution, smoking, illicit drug use, poor nutrition, chronic stress are some of the extrinsic factors that age and accelerate the process.
Intrinsic factors – genetics, hormonal changes, multiple diseases, poor hydration and reduced cellular pathways contribute to the natural aging process.
Regenerative Treatments for Facial Aging
Platelet Rich Plasma is an autologous blood derived concentrate that is rich in cytokines, growth factors and bioactive proteins. This concentrate has been proven in thousands of studies to rejuvenate and repair damaged tissues. PRP stimulates collagen synthesis, improves the skin microbiome and reduces fine lines and wrinkles. Platelet Rich Plasma injections are used solely for facial aging or in combination with other modalities to stimulate repair and regeneration of the tissues damaged by aging.
Platelet Rich Fibrin is commonly called the “second generation of platelet products”. Platelet Rich Fibrin is typically used to replace volume loss or in scar resolution. It is fantastic as a natural filler and the anti-inflammatory microenvironment that is generated by PRF makes it especially advantageous in inflammatory dermatological conditions. Since PRF has a fibrin matrix, the cytokines, growth factors and bioactive proteins are slowly released when compared to PRP. This extends the enhanced regeneration potential and increases the volume restorative properties. PRF fillers are utilized as a natural filler when compared to synthetic dermal fillers, promoting long term volume and tissue remodeling.
Exosomes are extracellular vesicles derived from stem cells that contain proteins, lipids and genetic material crucial for cellular communication and regeneration. Exosomes relay their information and orchestrate the regenerative process. They promote collagen production, reduce inflammation and enhance the overall healing of tissues. Multiple studies have demonstrated that exosomes improve skin elasticity, reduce fine lines and wrinkles and accelerate healing by enhancing tissue regeneration.
Peptides play a significant role in skin regeneration and rejuvenation by stimulating collagen and elastin production and improving the skin barrier. Some effective peptides for facial anti-aging include:
Matrixyl 3000 which is a combination of peptides that stimulates collagen production and reduces wrinkles.
GHK-Copper peptide promotes wound healing while improving elasticity and reducing inflammation. It is a naturally occurring peptide that is reduced in the plasma as we age. It is significant in angiogenesis and tissue repair.
Argireline is a peptide that inhibits muscle contraction. It functions as a natural Botox, reducing skin frown lines and wrinkles.
BPC-157 promotes tissue and wound healing in skin and muscle. It modulates stem cell production and increases fibroblast migration for regeneration.
How Long Do Facial Anti-Aging Results Last?
The longevity of results from these modalities varies on the individual. It is based on skin characteristics, treatment frequency and lifestyle factors. Some common durations of longevity are,
Platelet Rich Plasma typically last 6–12 months after a series of maintenance treatments every 3–6 months.
Platelet Rich Fibrin can last longer than PRP due to the slow release of growth factors. The results can be seen as long as 9–12 months after a normal treatment cycle.
Exosomes can last 12–18 months with noticeable increases in skin quality and elasticity over this period.
Peptides therapy is commonly used in combination but when used solely the effects can last 6 months or more.
Delivery Methods for PRP, PRF, Exosomes, and Peptides
Platelet Rich Plasma, Platelet Rich Fibrin, Exosomes and Peptides are usually not topical treatments although they can be used that way. Their ultimate action in reducing facial aging is experienced when delivered into the deeper layers of the skin. Modes of delivery include,
Injection is the most common mode of delivery.
Microneedling is the most common mode of delivery of these substances in most med spas and aesthetic offices today. The substance is “stamped” into the lower areas of the dermis by small needles. The punctures are visible, and a healing time is needed post treatment. Topical anesthesia is commonly used to alleviate the pain of the procedure. The results can last for up to a year.
Electroporation/Ionophoresis is a needle free technique to deliver the substances to the lower areas of the skin. This device uses electrical bursts of energy to open the bilipid layer of the cell wall. The process is reversible. While the cell wall has open “pores” iontophoresis uses a continuous low energy charge to repel the polarity of the substance and drive it down and into the cell. It acts like trying to put the same positive poles of a magnate together, they push each other away. Iontophoresis does the same, pushing the desired substance through the skin. This process is without pain and side effects.
Chemical electroporation is the use of substances that can do the same as the electrical device but over a longer time. Topical application, with the included substance, is placed on the skin and typically within a 24-hour period, it slowly migrates into the deeper tissues of the dermis to start the desired results.
Conclusion: A Natural Approach to Facial Anti-Aging
Facial aging is influenced by many factors, but with regenerative medicine effective solutions are now available. These provide lasting and natural appearing results. PRP, PRF, exosomes enhance the production of collagen and elastin that is needed for skin quality. Peptides further support skin regeneration and barrier function making a valuable addition to anti-aging treatments. With newer devices for regenerative aesthetics, these modalities can be delivered without discomfort and can be continued in the out of office setting to prolong the results.
Juventix Regenerative Medical: Advancing Aesthetic Solutions
Juventix Regenerative Medical is an industry leader in the regenerative medical field. Our Platelet Rich Plasma Kits are FDA cleared and designed for safety, sterility and effectiveness. Our kits are scientifically manufactured to produce a platelet concentrate, devoid of red blood cells with a minimum number of leukocytes that are critical to the regenerative process.
Juventix Regenerative Medical offers a patented LED Activator to activate the platelets and begin the regenerative process. This activation is a critical step in the release of growth factors, cytokines and bioactive proteins from the alpha granules contained on the platelets and is accomplished with LED light. This negates the use of chemical additives such as Calcium Chloride, Thrombin or Collagen. This mode of activation by LED light provides sustained growth factor release versus older methods of activation while adhering to the minimal manipulation standards of the FDA. This activation should always be accomplished after a gentle swirl of the centrifuged product to maximize the number of captured platelets.
Juventix Regenerative Medical supplies a patented Bio-Incubator to transform the Platelet Rich Plasma into an Injectable Platelet Rich Fibrin which can be used as a facial filler. The Platelet Rich Fibrin, commonly called the “second generation of platelet products” has different cytokines and growth factors than the original PRP. These different cytokines provide an anti-inflammatory microenvironment and can be used confidently in inflammatory conditions.
Innovative Devices for Regenerative Facial Aesthetics
Juventix Regenerative Medical offers the Radiance RF advanced microneedling system for skin rejuvenation and anti-aging. Radiance RF is a cutting edge subdermal adipose remodeling device that combines microneedling with radio frequency to stimulate collagen and elastin production. This device addresses the many issues of aging including fine lines, wrinkles and skin laxity. The radiofrequency facilitates the stimulation of deep collagen resulting in visible skin firmness and texture.
The newest addition for anti-aging at Juventix Regenerative Medical is the Apollo Duet. This innovative device is a needleless avenue to facial rejuvenation. It encompasses the dual action of electroporation with iontophoresis to introduce molecules into the dermal layers of the skin, all without needles. The Apollo Duet also contains radiofrequency which introduces fractional energy into the skin stimulating the contraction of lax tissues while stimulating the production of a new generation of tissue. Again, radiofrequency is applied without a needle or pain whatsoever.
Your Partner in Regenerative Anti-Aging Solutions
Juventix Regenerative Medical has a vast array of products, devices and services tailored for the regenerative professional. The Radiance RF, Apollo Duet, PRP, and PRF are a few of the many treatments that can be utilized in the treatment of anti-aging. Juventix Regenerative Medical has a chemical proration serum (Privive) for topical at home use, to continue the regenerative qualities of the treatments that are accomplished in the office.
The regenerative marketplace is exploding with technological advancements being added daily for both men and women. With our premier line of products, services and devices and guidance through our experienced staff, Juventix will aid and guide any regenerative professional in providing enhanced outcomes and increased patient satisfaction.
RESTORE, REVIVE, REGENERATE – JUVENTIX REGENERATIVE MEDICAL
Regenerative Regards,
Dr. Robert McGrath
